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In carefully selected, well-tolerant patients, some clinicians may consider starting at 5 mg with close follow-up, but the labeled 2.5-mg on-ramp remains the safest default

Rare but serious risks include: Pancreatitis : Severe abdominal pain should prompt immediate medical attention Gallbladder problems : Rapid weight loss can increase gallstone risk Diabetic retinopathy complications : In people with existing eye disease, rapid glucose improvement may temporarily worsen retinopathy, particularly with semaglutide [14] [15] Hypoglycaemia : Low blood sugar is uncommon with GLP-1 agonists alone but can occur if combined with insulin or sulphonylureas [17] [18] GLP-1 agonists are not recognised to directly cause dangerous blood pressure drops (hypotension) in most patients

Note: Market size and forecast figures in this report are generated using Mordor Intelligences proprietary estimation framework, updated with the latest available data and insights as of 2026

We don't have clinical trials for endometriosis

If you were taking 1.0mg from a 2.5mg/ml vial (40 units), switching to a 5mg/ml vial means drawing 20 units for the same 1.0mg dose

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