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Therefore, bariatric surgery in patients with PWS remains still controversial and requires the collaboration of an expert multidisciplinary team and the development of more innovative bariatric treatment plans tailored to patients with PWS to obtain effective and stable weight loss, and to reduce severe health complications in these patients Table 1

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As expected, refeeding induced a rapid decline in ghrelin to similar levels in female and male WT and Tmprss2 / mice (Figure 2K)