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Impact of glucagon-like peptide 1 receptor agonists and sodium-glucose transport protein 2 inhibitors on blood pressure and lipid profile

Safety Profile and Side Effects Retatrutide's adverse event profile is dominated by gastrointestinal effects including nausea, vomiting, diarrhoea, and constipation, and these are dose-dependent and transient

Skipping meals or eating mostly refined carbs can make swings worse

The present review ultimately weighs early concerns against increasingly consistent evidence that GLP-1 RA use does not raise overall cancer risk, clarifies that breast cancer risk appears neutral, and further highlights key mechanisms, such as the reduction of hyperinsulinemia and immune-microenvironment modulation, through which these drugs may improve rather than exacerbate malignancy outcomes

Another plausible mechanistic explanation for a diminished incretin effect is the TCF7L2 -dependent repression of GLP-1R and GIPR expression on the -cells [569]