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Month 2 (Step-Up): Amount: 1 ml vial Dosage: 0.5 mg (20 units) per week

There is no consensus on which dietary approach is best

In fact, one 2022 follow-up study showed that most weight lost on semaglutide was regained within a year of discontinuation

[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Samms RJ, Sloop KW, Gribble FM, Reimann F, Adriaenssens AE

At steady state, the peak-to-trough ratio (Cmax/Ctrough) is moderate, meaning that orforglipron plasma concentrations remain within a relatively narrow range between doses

However, the larger issue is that many people see the new drugs as a quick-fix solution