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Targeting JMJD6/PPAR/GPX4 axis overcomes ferroptosis resistance and enhances therapeutic efficacy in hepatocellular carcinoma

27 A recent phase II study of cilofexor given at doses of 30/day and 100 mg/day compared with placebo in 140 noncirrhotic NASH patients for 24 weeks showed a significant reduction in hepatic steatosis measured by magnetic resonance imaging-proton density fat fraction and a reduction in serum gamma-glutamyltransferase

This request was made in the interest of patient safety following reports of these side effects

Significantly reduces circulating triglyceride levels (reducing the risk of a heart attack or stroke)

Glucose-dependent insulinotropic polypeptide signaling in pancreatic -cells and adipocytes

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