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Metabolism (1966) 15:8657

GLP-1 has a short half-life of only two minutes, due to renal clearance and endogenous GLP-1 is degraded by the enzyme dipeptidyl peptidase IV (DPP-4) (2022)

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GLP-1R agonism reverses the neuronal toxicity associated with the synucleinopathy, through reduction of oxidative stress, improved mitochondrial and lysosomal function, reduced aggregation of -synuclein, and enhanced neuronal viability

[10] Alarmingly, within just one year of taking these medications, individuals might face muscle loss at a rate 2-3 times faster than this natural decline