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To cite this abstract in AMA style: Arthritis Rheumatol

Its currently in Phase 3 clinical trials and is not FDA-approved

Semaglutide at 2.4 mg has also been associated with a 20% reduction in the risk of heart attack or stroke in non-diabetic patients with obesity or overweight with existing cardiovascular conditions (Lincoff et al., 2023)

CNS-expression-pattern research on GLP-1R, GIPR, and GCGR is refining the mechanism map and suggesting that the therapeutic effects of incretin agonists may be more CNS-driven than the early pancreatic-focused pharmacology suggested

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[DOI] [PubMed] [Google Scholar] 100.Gao Y., Du L., Li Q., Li Q., Zhu L., Yang M., Wang X., Zhao B., Ma S