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doi: 10.1523/jneurosci.2212-10.2011 55 SisleySGutierrez-AguilarRScottMDAlessioDASandovalDASeeleyRJ
It uses liraglutide, a slightly different GLP-1 medication than semaglutide, and requires daily injections rather than weekly

Diarrhea: Gastrointestinal discomfort, including diarrhea, may appearparticularly with higher doses or rapid dose increases

Tirzepatides SURPASS programme demonstrated superior HbA1c reductions compared to semaglutide in head-to-head type 2 diabetes trials [2]
