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Front Pharmacol 12:648636 Ma J et al (2025) Tirzepatide administration improves cognitive impairment in HFD mice by regulating the SIRT3-NLRP3 axis

GLP-1 agonists mimic the GLP-1 hormone by releasing more insulin to help people with diabetes manage their blood sugar

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Nevertheless, because these mechanisms have been demonstrated mostly in short-lived organisms from the yeast model to the mice model [197], from bench to bedside, targeted different interventions to promote longevity, like exercise, nutrient supply reduction and food polyphenols, are optimal to implement [67,153,191,193,198]

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Contact them if you: Miss more than one dose Experience side effects lasting longer than 34 days Feel a dip in motivation Notice severe symptoms or face financial concerns In urgent cases, such as severe abdominal pain, symptoms of pancreatitis, or allergic reactions, contact your healthcare provider immediately