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GLP-1R signaling in the brain exerts antidepressive effects by improving cognitive processes, promoting neuroprotection and neurotransmitter release Patients suffering from depression are characterized by impaired neuronal activity and synaptic plasticity dysfunction, resulting in volumetric changes in brain regions which regulate emotions or the stress response such as the hippocampus and the prefrontal cortex

This can lead to reduced expression of GLP- 1 receptors and the development of GLP- 1 resistance

This was not a randomized control trial, rather we recruited participants already taking these medications, additionally we did not use a placebo for alcohol administration

doi: 10.1007/s00125-022-05746-x 15 LiXXiaoHMaYZhouZChenD

Ann Plast Surg

Among these patients, 45.2% achieved a dose of 1 mg (injectable), and 14.2% reached 14 mg (oral) [1]