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Susan Spratt, an endocrinologist and the senior medical director for the Population Health Management Office at Duke Health in North Carolina, said a monthly GLP-1 drug could be good for patients who struggle with sticking to the dosing schedule or who just prefer taking medication less often

GCGR agonism drives hepatic glycogenolysis and fatty acid oxidation, mechanisms that are distinct from and potentially complementary to GLP-1R-mediated appetite suppression and GIP-mediated adipose tissue effects

Cardiovascular Considerations Cardiovascular exercise plays a supporting role for body composition but should not dominate the training program for someone prioritizing muscle building

During the shortage, clinicians are also required to: Only prescribe GLP-1 RAs for their licensed indication Review the need for prescribing a GLP-1 RA agent and stop treatment if no longer required due to not achieving desired clinical effect as per NICE CG28 Avoid switching between brands of GLP-1 RAs, including between injectable and oral forms Where a higher dose preparation of GLP-1 RA is not available, do not substitute by doubling up a lower dose preparation Where GLP-1 RA therapy is not available, proactively identify patients established on the affected preparation and consider prioritising for review based on the criteria below

Fatigue and Mental Health Considerations Psychological screening is a required part of surrogacy

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