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Scopoletin protects retinal ganglion cells 5 from high glucose-induced injury in a cellular model of diabetic retinopathy via ROS-dependent p38 and JNK signaling cascade
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EMPA-REG not only showed that empagliflozin was safe, but it also showed a stunning, and largely unexpected, reduction in CV mortality, heart failure admissions, and total mortality (Figure 3)
In 2023 the firm abandoned development of lotiglipron after trial participants showed elevated liver enzymes, and the same year discontinued a twice-daily danuglipron dosing regime after almost three quarters of treated patients experienced nausea, while almost a half developed vomiting and a quarter diarrhoea
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Sleep problems may arise indirectly through gastrointestinal discomfort, blood glucose fluctuations, or metabolic changes
