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Pharmacoepidemiological studies using large healthcare databases have found associations between GLP-1 agonist use and reduced rates of alcohol-related hospitalizations, emergency department visits, and new diagnoses of alcohol use disorder

Vildagliptin and sitagliptin have IC50 values of 62 nM and 19 nM, respectively

The criteria below reflect eligibility used in Phase 2 and ongoing Phase 3 clinical studies only and should not be interpreted as future UK licensing or NHS commissioning criteria

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In addition to acting on other metabolically relevant tissues, vagal afferents contain TLR4 263 , and LPS impairs gutbrain vagal signaling 264,265
