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Most patients lose the largest percentage of weight in the first 6 months, with the rate slowing as the body adapts and approaches a new set point

it results from sustained and continuous research and development investment over an extended period of time

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Dual receptor activation might also stress metabolic systems or create unpredictable drug interactions

Another human study demonstrated a slight decrease in energy expenditure, but this decrease is not proportional to the weight loss of the experimental group receiving GLP-1 agonists, suggesting that GLP-1 agonists can attenuate some of the decrease in energy expenditure expected with a decrease in weight [49]

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