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Seminer, A
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Freezing a reconstituted peptide can be destructive
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Whether dual incretin receptor agonism can meaningfully exceed current cardioprotective thresholds remains uncertain
As endogenous GLP-1 has a very short half-life, these central actions are likely to be more relevant during therapeutic use of DPP4-resistant GLP-1R analogs, or in post-gastric bypass surgeries, in which GLP-1 equivalent levels, or postprandial GLP-1, respectively, are augmented and sufficient to elicit anorectic responses at these CNS targets
