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Efectos de los actuales y potenciales componentes asociados a GLP-1 en el contexto de frmacos multiagonistas y combinaciones Adpn: adiponectina

Among the various HFpEF phenotypes identified, the obesity-related phenotype characterized by visceral adiposity and insulin resistance appears to be the most prevalent (92)

Paraventricular hypothalamic nucleus GLP1 receptor effect on glycaemic control and energy balance GLP1 receptors are widely distributed within the paraventricular hypothalamic nucleus (Figure 2) (Larsen, TangChristensen, & Jessop, 1997)

It is evident that CNS GLP-1R signaling is essential for mediating the pharmacological action of GLP-1R agonists on energy metabolism as genetic deletion of CNS GLP-1R signaling in mice ablates the action of peripherally administered liraglutide on food intake and body weight reduction (Sisley et al., The hypothalamus has also been implicated as a major center for mediating the pharmacological effects of GLP-1R action on energy metabolism