average weight loss semaglutide vs Tirzepatide: How to Decide Which Is Best for You 1️⃣ How much do you want to lose? • Mild to moderate weight loss? Semaglutide (average 12–15%) • Significant weight Achieving Over 30% Body Weight

To date, few studies that evaluated the efficacy of GLP-1 RAs on NAFLD-related liver fibrosis are available [56,61,81,96,97,98] (Table 4)

Only one of them is really talking about the liver

PKA promotes exocytosis of insulin-containing vesicles from pancreatic -cells and increases glucose-dependent insulin secretion (15)

Like all licensed anti-obesity medicines it is not recommended in pregnancy, so effective contraception is important if pregnancy is not planned

For an expensive medication with real health implications, that is a risky bet

The Medicare GLP-1 Bridge program represents a historic shift in how the federal government views obesity treatment for beneficiaries, but its not clear what will happen beyond 18 months