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377 , 839848 (2017) J.F.E

Besides being more convenient for the patient, there seem to be added benefits of creating a more stable pharmacodynamics profile (i.e., reducing the peaks and troughs of drug action) as these drugs induce less nausea, a common side-effect of rapid-acting compounds (19, 50, 98, 194)

Exendin-4 induced retching-like behavior mediated by postsynaptic effect via AMPA receptors in the area postrema of mice

B., An improved synthesis of crystalline mammalian glucagon

Additionally, these agents increase the expression of neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which support the survival and maturation of new neurons (107)

Conclusions GLP-1 RAs represent a paradigmatic transformation in modern therapeutics, evolving from glucose-lowering agents to comprehensive multi-system interventions that address fundamental pathophysiological processes across diverse medical conditions