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Skyrizi (risankizumab) is used for moderate-to-severe plaque psoriasis and active psoriatic arthritis in patients 6 years and older, and Crohn's disease and ulcerative colitis in certain adults

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report here on a GIPR antagonist conjugated to GLP-1 analogues that reduces body weight and improves metabolic markers in preclinical and phase 1 clinical settings.