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Clinical trials, including the STEP programme (Semaglutide Treatment Effect in People with obesity), demonstrate that these effects are most pronounced during the initial weeks of treatment and when increasing to higher doses
2813-LB: CT-388, a cAMP Signal-Biased GLP-1/GIP Receptor Agonist, Achieves Clinically Meaningful Weight Loss in People With Overweight/Obesity: A 48-Week Phase 2 Study LINGVAY I, JASTREBOFF A , LENDER D, BAYS H, CHAKRAVARTHY M, LE ROUX C, SHEARER-KANG E, PALERMO G, WILLIS J, STEINBERG A, SHARP S, BOLLEPALLI S, KIM K

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These cells then, in turn, secrete numerous cytokines including IL-4, IL-5, IL-9, and IL-13, which stimulate structural cells in the lung such as goblet cells and smooth muscle cells to cause airway remodeling

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