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IR is associated with several groups of abnormal syndromes that include obesity, diabetes, metabolic dysfunction-associated fatty liver disease (MAFLD), cardiovascular disease, polycystic ovary syndrome (PCOS), and other abnormalities

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Daily injection with the weight-loss drug liraglutide was more effective than placebo (both combined with lifestyle interventions) at reducing weight in children 612 years of age with obesity.

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GLP-1 drugs are reshaping surgical care, with evolving guidance on perioperative use, weight optimization, nutrition, and outcomes.

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