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Front Med (Lausanne) (2022) 9:875430

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Both groups received the maximum tolerated dose of their medication: Tirzepatide group: 10 mg or 15 mg weekly (Zepbound) Semaglutide group: 1.7 mg or 2.4 mg weekly (Wegovy) Participants had a BMI of 30 or higher, or a BMI of 27 or higher with at least one weight-related health condition

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Consistent with previous studies, our findings confirm that both semaglutide and tirzepatide improved the metabolic phenotype of HFHFD-fed mice, as evidenced by reduced body weight, improved lipid profiles, and enhanced insulin sensitivity