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However, conservative approaches such as lifestyle modification, dietary control and physical activity are usually unsatisfactory to achieve satisfactory weight reduction in patients with obesity [35-37] Successful obesity management expands beyond weight loss, as it is important to highlight the assessment of the life quality and the prevention of obesity-related comorbidities [38]

Los medicamentos agonistas del receptor GLP-1, como semaglutida y dulaglutida, se utilizan para tratar la diabetes tipo 2 y el manejo del peso corporal
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doi: 10.1001/archinternmed.2009.20
Collagenase clostridium histolyticum-aaes (Qwo) was FDA-approved for cellulite but has limited availability due to significant bruising concerns

With respect to the statistical analysis of the included studies, efficacy analyses were conducted using the FAS, which followed an intention-to-treat principle