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Note that oral semaglutide (Rybelsus) does not cause injection site reactions

So there is a little bit of concern about that. Its a concern that has been pervasive enough for existing drugs that Lilly released a commercial ahead of the 2024 Oscars urging against vanity use

doi: 10.1172/JCI146353

"Also, our findings apply only to diabetic patients aged 66 years or older, and cannot be directly generalized to non-diabetic individuals using GLP-1 receptor agonists for weight loss," Shor told Fox News Digital

But if threatened and unable to escape or hide, they may bite a predator

They did these at both the start and end of the study