can you use glp 1 with sglt2 vs GLP-1 for CKD: Which Is Better? Combining glucagon-like peptide-1 receptor agonists

Cosmos Study October 14, 2025 Dual-Team Study Team A:Kersten Bartelt, RNEric Barkley Team B:Joel Jones, PharmDJoe Deckert, PhD Key Findings Among non-diabetic patients without chronic kidney disease (CKD), there was a minimal increase of 0.01 mg/dL to 0.02 mg/dL in serum creatinine in the months following initiation of semaglutide, liraglutide, or tirzepatide

Dizziness can occur, especially if food intake drops too aggressively

Key practical recommendations from clinical experts for GLP-1 users include: Assess and gradually increase dietary fiber intake toward 25 to 30 grams per day for adults

Youre likely familiar with semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA) used in commercially available prescription medicines for treatment of type 2 diabetes and obesity

37 Through their anti-inflammatory and neuromodulatory actions, GLP-1 RAs may offer an additional mechanism for migraine control, particularly in cases with obesity, as it is a known risk factor for chronification

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