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If used properly, they are believed to be safe, but patients should be carefully monitored during use by an experienced medical practitioner

Discontinuation was defined as a gap of at least 90 days after the last prescription

Using Zovirax at the first signs of a cold sore, such as tingling, itching, or burning, can help speed up healing and reduce how long the cold sore lasts

Recent expert consensus from 20232025 characterizes these medications as metabolic disease modifiers rather than simple glucose lowering agents

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Kim said the framework was created too long ago and has not kept pace with newer drugs or guidelines that no longer treat metformin as the only first-line option