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In a separate analysis, lixisenatide reduced incident macroalbuminuria, while adjustments for baseline characteristics such as age, blood pressure and eGFR, as well as on trial HbA1c, blood pressure and weight, did not significantly attenuate the association [28]

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In contrast, GLP-/GIP dual agonists, while controlling blood sugar, can more comprehensively regulate lipid metabolism and reduce the risk of cardiovascular diseases [138,139]

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