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However, the SURPASS and SURMOUNT trials did not report a significant VTE signal

A practical approach

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Industry leaders Novo Nordisk A/S and Eli Lilly and Company currently dominate the market through blockbuster injectable products including Ozempic(R), Wegovy(R), Mounjaro(R) and Zepbound(R)

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Third, to propose a negative-selection framework that clearly delineates which peptides and proteins should not be developed as oral dosage forms, using oral semaglutide and oral octreotide as boundary cases rather than templates