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Researchers may also study receptor-binding profiles, degradation patterns and the behaviour of the compound under controlled storage and handling conditions

The trial also reported secondary improvements in knee-pain scores, which matters for the eventual label scope but does not change the regulatory math for an obesity indication

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doi: 10.1111/dom.13955 102 MarguliesKBHernandezAFRedfieldMMGivertzMMOliveiraGHColeRet al

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Combination with Metformin or Metformin with SGLT-2 Inhibitors In a 26-week, double-blind, double-dummy trial (Trial 4, NCT02863419), 711 adult patients with type 2 diabetes mellitus on metformin alone or metformin with SGLT-2 inhibitors were randomized to RYBELSUS 14 mg once daily, liraglutide 1.8 mg subcutaneous injection once daily or placebo
