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Conclusions Consistent with clinical trials, real-world tirzepatide treatment was associated with greater 6-month weight reduction and more frequent achievement of weight-reduction targets and improvements in select cardiometabolic parameters than semaglutide among adults with obesity without diabetes

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Studies examining receptor binding have shown that GLP-RTdemonstrates strong activity at the human GIP receptor while maintaining measurable activity at both GLP-1 and glucagon receptors, creating a balanced activation profile that allows researchers to explore receptor crosstalk and multi-pathway metabolic signaling [2]

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