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[DOI] [PMC free article] [PubMed] [Google Scholar] 133.Banerjee M, Maisnam I, Pal R, Mukhopadhyay S

Patients should talk to their health care provider to evaluate their unique needs and conditions

If semaglutide alone achieves suboptimal results after an appropriate trial period, genetic insights and detailed metabolic assessment provide a rational foundation for considering whether additional compoundslike oral semaglutide, tirzepatide, or the dual GLP-Squared formulationmight be more suitable than reaching for off-label combinations
Lilly describes retatrutide as investigational, meaning patients should be cautious about any source that markets it as a routine approved weight loss treatment

Foods may taste sweeter, saltier or richer than before, and long-time favourites can lose their appeal," says Dr Kwong

