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They are sub-populations of common diseases, defined narrowly enough to qualify for orphan status

Understanding why coverage is challenging helps set realistic expectations

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Can GLP-1 medications impact substance use

In a study using cultured rat hippocampal neurons, pre-treatment of nerve cells with GLP-1 resulted in a weakened Ca 2+ response to glutamate and weakened membrane depolarization ( Effects on Parkinsons Disease Parkinsons disease (PD) is a chronic neurodegenerative disease that affects the central nervous system and the second most common neurodegenerative disease after AD (56)

Larger sample sizes are crucial to account for baseline imbalances between study groups and to better elucidate the specific impact of GLP-1 receptor agonists on both the symptoms and progression of PD