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Tirzepatide carries a boxed warning regarding thyroid C-cell tumors, based on rodent studies showing increased incidence of medullary thyroid carcinoma

Singh: conceptualization, investigation, manuscript review and editing

Both drugs mimic the naturally occurring hormone GLP-1 to help regulate blood sugar and reduce cravings

For men and women on GLP-1 medication for weight loss, the biggest hurdle can be coping with the bodily effects of rapid weight loss

GLP-1 receptor agonist (GLP-1RA), a novel hypoglycemic agent, not only promotes insulin synthesis and secretion, but also decreases glucagon secretion in cells while promoting insulin secretion from cells of the pancreas, reduces food intake, and delays gastric emptying.2224 The anti-inflammatory properties of GLP-1RA first originated from studies on pancreatic cells, followed by studies on the heart, vascular system, and the liver.2527 In fact, GLP-1 RA can regulate several molecular pro-inflammatory factors, such as glucose toxicity, oxidative stress, and lipid toxicity.28 In addition to treating type 2 diabetes mellitus (T2DM), GLP-1RA has been used to explore the treatment of PCOS