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Their anti-inflammatory action is essential, since low-grade inflammation is a key factor in the perpetuation of cardiovascular damage in patients with HFpEF, especially in the presence of obesity

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Patients who experience rapid weight loss should undergo gallbladder ultrasonography to screen for imminent biliary pathology

Liu S, Wang ZF, Su YS, Ray RS, Jing XH, Wang YQ, et al

However, cardiovascular outcome trials (CVOTs) have not demonstrated a synergistic or additive protective effect of combined therapy on MACE or renal endpoints

Therefore, we conducted sensitivity analyses to determine whether baseline HbA 1c or prior metformin treatment were mediating factors