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They stimulate insulin secretion and inhibit the release of glucagon by the beta and alpha cells of the Langerhans islets of the pancreas, thereby reducing postprandial plasma glucose levels.68 They also reduce gastric emptying time and body weight

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The LES is a muscular valve that normally keeps stomach contents where they belong

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Some of the evaluated GLP-1 RAs were associated with a significant increased risk of abdominal pain, in the following order: liraglutide (RR 2.077 [95% CI 1.0602, 4.0703
