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Therefore, the efficacy and specific benefits of GLP-1RAs in HFpEF require further investigation

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Notably, in rat 6-OHDA models, DA-CH5 and exendin-4 have been suggested to exert their neuroprotective by inducing autophagy and inhibiting apoptosis, particularly by enhancing autophagic activity and reducing the Bax/Bcl-2 and active caspase-3/caspase-3 ratios [35]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 39.DailyMed - WEGOVY- semaglutide injection, solution n.d