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Studies in humans with resection of different parts of the small intestine demonstrated that the incretin effect and the GIP response to oral glucose did not correlate the incretin effect was better correlated with preservation of the ileum [79]

We considered a subject as having been treated with GLP-1 M only if there were at least two different medication entries referring to GLP-1 M treatment in the subject record, and GLP-1 M treatment occurred together with or subsequent to ICD codes for T2D (10,517 subjects were selected using these rules)

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These include: Nausea and vomiting Diarrhoea Reduced appetite and fluid intake These effects can lead to inadequate hydration and depletion of essential electrolytes such as sodium, potassium, magnesium, and calciumall of which are crucial for normal muscle function

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