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Limitations include the post hoc design, lack of multiplicity adjustment, and incomplete capture of background therapy changes

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After adjustment for sex, BMI, hsCRP, and sCD163, semaglutide significantly decreased epigenetic aging: PCGrimAge (-3.1 years, P = 0.007), GrimAge V1 (-1.4 years, P = 0.02), GrimAge V2 (-2.3 years, P = 0.009), PhenoAge (-4.9 years, P = 0.004), and DunedinPACE (-0.09 units, 9 % slower pace, P = 0.01)

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Formulated in MCT oil for SubQ administration, Andrenyx is available in 50 mg, 75 mg, and 100 mg doses, supplied in packs of 4 single-dose syringes