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268 Physiologic GLP-1 secretion is a complex, incompletely understood process, with early studies suggesting potentiated release through nutrient supplementation, whole foods, dietary patterns, and microbiome alterations

they may heal spontaneously over 1224 months

Serious adverse effects include pancreatitis, gallbladder disease, acute kidney injury, and increased heart rate

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The metabolic shift produces measurable changes in insulin sensitivity, inflammatory markers, triglyceride levels, and appetite-regulating hormones

Semaglutide treatment in our case series of patients with PWS without diabetes led to weight reduction and/or weight maintenance, as well as to appetite suppression as reported by patients and caregivers