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No recent review has showed multiple antidiabetic plants while linking their bioactive compounds to shared and distinct molecular pathways, including glucose homeostasis, oxidative stress, inflammation, and metabolic regulation

Inspired by this idea long acting dual agonists were developed to treat type 2 diabetes and several obesity related health issues

Retatrutide is being studied as a triple-agonist acting on GLP-1, GIP, and glucagon , while semaglutide and tirzepatide act on fewer pathways.

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For Dr Sinclair, the unknowns of the knock-off retatrutide are the primary concern
