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Other clinically developed small-molecule GcgR antagonists include PF-06291874, LY2409021, and LGD-6972 (RVT-1502), all of which have advanced to clinical trials but ultimately were not pursued further for the treatment of T2D or obesity due to the associated increases in circulating LDL-C, body weight, hepatic fat, and blood pressure [31]

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Li, M., et al., Functional inorganic nanoparticles in cancer: Biomarker detection, imaging, and therapy
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Skov J, Dejgaard A, Frkir J, Holst JJ, Jonassen T, Rittig S, et al

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