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PMCID: PMC4808277
158,159 The AUC of S- and R-warfarin was not affected by dulaglutide and tirzepatide administration
10.1074/jbc.M106692200
Oral semaglutide GLP-1 RAs were developed as injectable therapies for type 2 diabetes because absorption of a polypeptide from the gastrointestinal tract after swallowing was considered unfeasible, as the strongly acid environment and action of peptidases in the stomach rapidly lead to its breakdown
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