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They found that, while GLP-1s were originally approved for obesity in 2014using the active ingredient liraglutide, under the brand name Saxendaclaims for the drugs rapidly increased after the U.S

For patients with severe renal impairment (eGFR less than 30 mL/min/1.73 m2) or with end-stage renal disease (ESRD) requiring hemodialysis or peritoneal dialysis, the dose of JANUVIA is 25 mg once daily

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Therefore, overall, the benefit of GLP-1RAs for heart failure has been difficult to confirm (Figure 1)

In addition, since metformin is known to have beneficial effects in PCOS, any improvement in the prespecified outcome parameters or even equivalence would place GLP1RAs in a favorable position

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