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A 20mg/mL vial contains twice as much medication in the same volume

A phase 3 clinical trial found a high dose of tirzepatide helped patients lose 22.5% of their body weight on average, or about 52 pounds, better than any medication currently on the market

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or cagrilintide at a dose of 100 nmol/kg

Renal effects are primarily related to volume depletion from gastrointestinal side effects rather than direct nephrotoxicity