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Theoretical analysis suggests complementary mechanisms with potential insulin resistance concerns

They are not recommended for people with certain thyroid conditions, hypertension, a history of pancreatitis, or those who are pregnant or planning to become pregnant

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Diz-Chaves Y., Herrera-Prez S., Gonzlez-Matas L.C., Lamas J.A., Mallo F

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There were no hepatotoxicity signals in the overall obesity trial population or in the subset of participants with MASLD through 48 weeks

Diarrhoea and constipation are also frequently reported, signalling a need to consider patient dietary adjustments