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GLP-1 therapies work best when combined with lifestyle modifications

Although the increase is small, it tends to persist during treatment

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K.rskovC.Reedtz-RungeS.KaastrupP.et al (2014)

And how might that differ from what we can activate peripherally with these medicines to produce powerful weight loss? Perhaps, he suggested, GLP-1R agonists that get into the brain more efficiently might produce more neuroprotection, but would they also lead to more adverse events

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