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Weeks 9 through 12: the three-month milestone at 1.0 mg The second dose escalation happens at week nine, bringing you to 1.0 mg weekly

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Lifestyle Changes That Help Small changes in your daily routine can prevent heartburn: Sleep Smart: Raise the head of your bed 6-8 inches using bed risers or blocks Use a wedge pillow designed for acid reflux Sleep on your left side (this keeps acid down better than your right side or back) Dress Comfortably: Wear loose pants, skirts, and dresses Avoid tight belts and waistbands Choose stretchy fabrics that dont squeeze your belly Lose Weight if Needed: The good news is that semaglutide helps you lose weight, and weight loss often improves acid reflux over time

Discontinuation rates due to adverse events ranged from 0-6% depending on the dose group, which is comparable to or lower than rates seen with semaglutide (7% in STEP 1) and tirzepatide (4-7% in SURMOUNT-1)