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In 1986 , a truncated form of GLP-1 (specifically GLP-1(736) amide) was isolated from the gut and shown to have potent effects: it stimulated insulin secretion and suppressed glucagon secretion in the presence of elevated glucose ( [35] )

[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Ferdinand KC, White WB, Calhoun DA, Lonn EM, Sager PT, Brunelle R, Jiang HH, Threlkeld RJ, Robertson KE, Geiger MJ

One conceived in the wake of recombinant DNA technology in the 70s, shaped by early anglerfish experiments in the 80s, and given further structure by elegant biochemical studies of GPCR signaling in the 90s

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The cardiovascular side effects that sank sibutramine are still being studied

If so, the two types of heart failure may be very similar, except that the cause of heart failure with a preserved ejection fraction may not be the same as that with a reduced ejection fraction