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GLP-1 drugs are far more powerful and longer-lasting than natural GLP-1

GLP-1RA is safe for use in children and adolescents over the age of 10 years, and some formulations have been approved for pediatric T2DM or obesity

doi: 10.1007/s00213-005-2270-y 138 McQuadeR.SharpT

Tirzepatide is a dual-action medication that targets both GLP-1 and GIP receptors, which is why clinical trials have shown it producing greater average weight loss than semaglutide alone

In previous GLP-1- or exendin-P5-bound active structures 3,4 , the ECD shows a fully extended open conformation, whereas in the peptide 5-bound active-like structure 12 , the ECD is less extended since it makes fewer interactions with the truncated peptide 5