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Whether the single molecule GLP-1/Gcg coagnonist has a similar CNS pattern of activation requires further investigation

Research from the SURMOUNT-4 trial showed that participants who discontinued tirzepatide regained roughly two-thirds of the weight theyd lost within one year

Different methods can be used for this purpose (24 h recall, dietary record, food frequency questionnaire, dietary history), but the choice depends on patients compliance [59]

Human C-cells appear to express far fewer GLP-1 receptors, which may explain why similar tumor patterns have not been consistently observed in clinical populations

c Participants with major depressive disorder or generalized anxiety disorder whose disease state is considered stable for the past 2 years and expected to remain stable throughout the course of the study, in the opinion of the investigator, may be considered for inclusion if they are not on excluded medications

STEP 4 41 was a 68week withdrawal trial, designed to assess the effect on weight change of continuing versus discontinuing onceweekly subcutaneous semaglutide 2.4 mg after an initial 20week semaglutide runin period